Parasitic Helminths: New Weapons against Immunological Disorders
نویسندگان
چکیده
The prevalence of allergic and autoimmune diseases is increasing in developed countries, possibly due to reduced exposure to microorganisms in childhood (hygiene hypothesis). Epidemiological and experimental evidence in support of this hypothesis is accumulating. In this context, parasitic helminths are now important candidates for antiallergic/anti-inflammatory agents. Here we summarize antiallergic/anti-inflammatory effects of helminths together along with our own study of the effects of Schistosoma mansoni on Th17-dependent experimental arthritis. We also discuss possible mechanisms of helminth-induced suppression according to the recent advances of immunology.
منابع مشابه
Biological and Immunological Reactions in Parasitic Diseases
Processed antigen reacts selectively with lymphocytes bearing .appropriate surface immunoglobulin molecules resulting in the clonal proliferation of these cells, producing circulating immunoglobulin (humoral immunity) or non-circulating immunoglobulins (cellular immunity). High levels of circulating immunoglobulins (lgM & lgG) occur in protozoa and helminths infections. Reaginic antibodies a...
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عنوان ژورنال:
دوره 2010 شماره
صفحات -
تاریخ انتشار 2010